0067 Chemogenetic Silencing of Hypoglossal Motor Neurons Creates a Model of Upper Airway Obstruction During Sleep
نویسندگان
چکیده
منابع مشابه
Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. OSA leads to high cardiovascular morbidity and mortality. The pathogenesis of OSA has been linked to a defect in neuromuscular control of the pharynx. There is no effective pharmacotherapy for OSA. The objective of this study was to determine whether upper airway patency can be improved using chem...
متن کاملChronic recordings of hypoglossal nerve activity in a dog model of upper airway obstruction.
The activity of the hypoglossal nerve was recorded during pharyngeal loading in sleeping dogs with chronically implanted cuff electrodes. Three self-coiling spiral-cuff electrodes were implanted in two beagles for durations of 17, 7, and 6 mo. During quiet wakefulness and sleep, phasic hypoglossal activity was either very small or not observable above the baseline noise. Applying a perpendicula...
متن کاملHypersomnolent and nonhypersomnolent patients with upper airway obstruction during sleep.
When the syndrome consisting of sleep-induced apnea and hypersomnolence is due to upper airway obstruction, the hypersomnolence is believed to be the direct result of deprivation of sleep related to such obstructions. The purpose of this report is to describe a group of four asymptomatic subjects with upper airway obstruction during sleep. These subjects were matched with a group of patients wi...
متن کاملAirway Surgery for Obstructive Sleep Apnea and Partial Upper Airway Obstruction during Sleep
5 Perttu Halme Airway surgery for obstructive sleep apnea and partial upper airway obstruction during sleep. Department of Otorhinolaryngology – Head and Neck Surgery, University of Turku, Finland. Annales Universitatis Turkuensis, Ser. D, Medica – Odontologica, 2011, Turku.
متن کاملProlonged partial upper airway obstruction during sleep – an underdiagnosed phenotype of sleep-disordered breathing
Obstructive sleep apnea syndrome (OSAS) is a well-recognized disorder conventionally diagnosed with an elevated apnea-hypopnea index. Prolonged partial upper airway obstruction is a common phenotype of sleep-disordered breathing (SDB), which however is still largely underreported. The major reasons for this are that cyclic breathing pattern coupled with arousals and arterial oxyhemoglobin satur...
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ژورنال
عنوان ژورنال: Sleep
سال: 2018
ISSN: 0161-8105,1550-9109
DOI: 10.1093/sleep/zsy061.066